Can't be bothered searching for the post where I said it, but about the time the new king of the hill was implemented I was talking about how drugs should include negative factors, so any cocktail would result in less good boosts, but more widely spread and for a higher cost.
This will be how it will work.
The effects will also be for longer (less micromanagement to remain drugged all the time) and will have one effect only (not + for 10 minutes followed by a - for 10 minutes ... this is so drugged chars don't have enforced periods where they can't play).
So, much smaller boosts but a lot more user friendly.