Every bartender needs alcohol. Every Weapon Merchant needs Ammo. An NPC misses his old dog, wants you to get him a new one.
Personally, I'm a slaver, there could be all kinds of quests involving the capture of particular slaves.
Clear out various nests of rats, pigrats, molerats, geckos, Deathclaws, ect, ect
Take a child to the Amusement Park (getting them there alive would be a bitch)
