I know it's been suggested somewhere before, but having backpacks or tools which give you a bonus to carry weight or a skill when held would be nice.
I mean, there's supposed to be items like that already. For example the paramedic bag is supposed to give a bonus to first aid when you use it, currently, it doesn't do anything.
But with the fact that some skills like science, and repair take such high skills to use, it would make sense that using a tool would increase your chance to repair.
Also backpacks would make lovely additions for those mining trips or when you plan to trade a lot of things.
It would be like +11kg while held, not that great, and it takes up a free hand, so Stong Back and Pack Rat are still useful perks.