Everything except LK and CH, which are fine at 1's and would not be crippling for a person to have in real life.
ST less than 3 = You are extremely frail and require a caregiver to lift your groceries.
PE less than 3 = Driving is out of the question, you're lucky to be able to detect night and day.
EN less than 3 = You can't get out of bed, traveling over the World Map by foot is impossible.
IN less than 3 = Too stupid to use tools or weapons, requires constant supervision.
AG less than 3 = Your status as a landwhale makes it impossible to run from encounters, walk as if you have two crippled legs.