Check this out.
If you have mega powerfist u make 20-40 dmg + 15 (10str melee damage + heavy handed + 3xbonus damage hth) +5 vs living creatures (anatomy) x 12
25x12=300 and 60x12=720
So in round u can deal 300-720dmg if theres no missed hits. Am i right?
But anyway u have to get close to your enemy first. With sneak 300% u can get only 3 hexes from enemy. That suck.
Don't forget about DR. Critters have not bad DR vs all types of damage. But, I think Wiki isn't right. Because if watch Radscorpion's defence, you see:
Defense Resistance Threshold
Normal 10% 4
Laser 10% 4
Fire 10% 4
Plasma 10% 4
Explosive 10% 4
Electrical 10% 4
EMP 10% 4
But, I noticed, that normal type weapons deal MUCH more damage, than laser and fire. You'll deal min. damage with laser pistol, even magneto-laser pistol. That's really small energy cell wasting, I think you'll kill them faster with 10mm pistol. Also these damned radscorpions do not die so fast by flamer, I really hate them, if not playing by small gunner. "Electrical" type damage (power fist and cattle prod) is most uncommon type, and only Tesla Armor have great resistance vs this type of armor. But critters MUST (may be...) have the same resistances vs all types. Anyway you'll get 12 strikes, so Treshold will apply on every strike, so it much less damage. ;p