i don't think it will be implemented , until we are far in testing the 3d era, since this will need brand new models, animations, placeholders, skins, and of course balance.
In any case, ghouls should be able to run, but suffer from a lack of maximum strength, while enjoying the benefits from an upgraded intelligence
Super mutants will suffer from reduced agility and intelligence, but will have a benefit in the strength and endurance aspects.