So after wipe they'll have EXACLY same builds, just powered by 2 points in the charisma. I see no point in this everything. Simply, make implants achievable after LONG quest, make implants priceless, costing +999999 caps, make getting implants something special like killing Diablo-quest. Or make it in the way if you choose + INT implant, you CAN'T leave Vault City Faction, you CAN'T be friend of a gang, etc.
Jet for doctors? No, no, no. Make new profession (druggist, 2 levels), expand limit of proffessions to 5, add requierment of doctor [2] to it and then it'll work.
Anti-jet only for druggist [2] and doctor [3]

One thing I'd suggest, seeing as how we're talking about charisma, is that people with horrible charisma (1) can't join parties. If your character is built like a loner, better be prepared to be one.
That won't work. We got radio-channels for making party encounters now.
Get over it. Charisma 1 don't make you cannibal. Maybe people don't like you, don't want to talk with you. OR you just hate the humankind, you won't even try to contact with the others.