Hgiher tier things will still be craftable in places such as Mariposa, this will generally be the quicker way - they're unguarded places, you take the risk and get the reward.
However there will be other places where you can earn access to craft the higher tier stuff, which will be "un-risky", if that were even a word.
Of course weak healing powder isn't higher tier, so won't be affected by any of that - Lexx refers to something different, which will be for lower tiered stuff.