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[bobek289]

Is it possible to use drugs before gaining level for extra stats, just to be able to take perk?

[manero]

No

[bobek289]

then drugs effects like buffout and psycho on endurance is useless, since endurance have efects only on rad res, healing rate, and poison res.  And to be honest healing rate is only good thing but no one wait to be healed with healing rate since it is too slow

[runboy93]

Of course it's not possible, because drug effect will off in time.
If this way perks is possible to take then they would vanish when drugs effects off xD

[RavenousRat]

EN gives you save throws against critical effects, probably all critical effects except for bypass (it's LK based), but I'm not sure. It means that you'll be less likely to knocked down/out, crippled, instakilled.
And then you can take Stonewall perk with 8 EN only if you're planning to eat buffout and can't, for some reason, have 10 EN to use that perk on maximum.
But really yes, EN from buffout and psycho in general almost useless and of course it should change your HP in real time, so even 9 7 5 3 EN builds could be viable if used with Psycho +some drugs can negate EN. But it belongs to suggestions.

[bobek289]

you mentioned stonewall. Is there another purpose of that perk except less chance to be knocked down? I took stonewall with one of my alts with 8 EN. But it was still common thing to be knocked down 

[RavenousRat]

you mentioned stonewall. Is there another purpose of that perk except less chance to be knocked down? I took stonewall with one of my alts with 8 EN. But it was still common thing to be knocked down 

You need 10 EN to have immunity vs KD.
Also it gives (EN-5)*10% immunity vs KOs.
With 8 EN you'll have 80% resistance against KDs and 30% against KOs.