I've seen a lot of complaints about Power Armor and various kept-out-of-game weapons being too strong for our current crop of tweaked PVPers. So why not make it that a character completely slanted towards combat cannot use these items at all?
Example: To use Power Armor, your character cannot use any drugs, any toughness perks, or adrenaline rush. Certain AC perks will be blocked as well.
Example: To use Gauss Rifle, your character cannot use Right Between the Eyes, Better Criticals, Bonus Ranged Damage, etc.
Why not have the player with civilian perks and skills, yet garbed in A+ gear, stand on a more equal footing with the current ape, who has better perks but gear that won't be quite as good?
Fonline could then be a battle between those who follow the "Path of the Chosen"--those who use the most expense gear and excel in non-combat skills--and the "Raiders", those who use more inexpensive gear, drugs, and builds honed directly for combat.